Revolutionizing the treatment of chronic disease.

Leveraging our NanoPortal technology, we are developing a portfolio of highly differentiated products comprised of miniature, sub-dermal drug implants.

Our Pipeline

Indication
Feasibility
Pre-Clinical
Clinical
Market Size
Type 2 Diabetes
NPM-119

exenatide

>$20B
Obesity
NPM-139

proprietary compound

>$19B
Human NASH
(Non-Alcoholic Steatohepatitis)
NPM-159

proprietary compound

>$18B
Feline Pre-Diabetes & Diabetes
OKV-119

exenatide

>$500M
Indication
Type 2 Diabetes
Feasibility
Pre-Clinical
Clinical
Market Size
NPM-119

exenatide

>$20B
Indication
Obesity
Feasibility
Pre-Clinical
Clinical
Market Size
NPM-139

proprietary compound

>$19B
Indication
Human NASH
(Non-Alcoholic Steatohepatitis)
Feasibility
Pre-Clinical
Clinical
Market Size
NPM-159

proprietary compound

>$18B
Indication
Feline Pre-Diabetes & Diabetes
Feasibility
Pre-Clinical
Clinical
Market Size
OKV-119

exenatide

>$500M
Indication
Type 2 Diabetes
Feasibility
Pre-Clinical
Clinical
Market Size
NPM-119

exenatide

>$20B
Indication
Obesity
Feasibility
Pre-Clinical
Clinical
Market Size
NPM-139

proprietary compound

>$19B
Indication
Human NASH
(Non-Alcoholic Steatohepatitis)
Feasibility
Pre-Clinical
Clinical
Market Size
NPM-159

proprietary compound

>$18B
Indication
Feline Pre-Diabetes & Diabetes
Feasibility
Pre-Clinical
Clinical
Market Size
OKV-119

exenatide

>$500M

Overview

A miniature, GLP-1 agonist implant designed to address medication non-adherence and improve tolerability.

Built with our NanoPortal technology, NPM-119 is designed to provide steady, long-term therapeutic delivery of exenatide for at least six months.

By assuring medication adherence, NPM-119 may free patients with type 2 diabetes from burdens associated with oral and injectable medications, as well as provide confidence to physicians, caregivers and loved ones that patients are receiving the intended therapeutic benefits from their medicine.

Target

Under investigation for the treatment of type 2 diabetes and obesity.

Medication non-adherence affects an alarming number of patients – approximately 50%, including those taking daily pills. Non-adherence may contribute to the gap in real-world effectiveness compared to the efficacy reported from randomized, controlled, clinical trials.

Development

Phase 2 clinical trial.

In 2023, we intend to file an Investigational New Drug application with the U.S. FDA to support the initiation of a Phase 2 clinical study of NPM-119 called LIBERATE-1.

LIBERATE-1 is the first clinical study investigating the effects of NPM-119 in patients with type 2 diabetes and of our platform NanoPortal implant technology.